serum nx-dcp as a new noninvasive model to predict significant liver fibrosis in chronic hepatitis c
نویسندگان
چکیده
conclusions nx-dcp correlated positively with fibrosis stage and could discriminate well between hcv-related patients with or without significant fibrosis. moreover, nx-dcp had a similar predictive ability to the abovementioned models, and thereby could be a new noninvasive prediction tool for fibrosis. results increase in serum nx-dcp was significantly related to increase in fibrosis stage (p = 0.006). moreover, nx-dcp was a multivariate factor associated with the presence of significant fibrosis f 3-4 (median 21 of f0-2 group vs. median 22 of f3-4 group with p = 0.002). the auc of nx-dcp showed no significant differences compared with those of the ast-to-platelet ratio index (apri), modified-apri, the göteborg university cirrhosis index (guci), the lok index, the hui score, cirrhosis discriminating score (cds) and the pohl score (p > 0.05). patients and methods we performed a prospective cohort study on a consecutive group of 101 patients who underwent liver biopsy for hcv-related liver disease at kobe university hospital. laboratory measurements were performed on the same day as the biopsy. factors associated with significant fibrosis (f3-4) were assessed by multivariate analyses. a comparison of predictive ability between multivariate factors and abovementioned noninvasive models was also performed. background finding a noninvasive method to predict liver fibrosis using inexpensive and easy-to-use markers is important. objectives we aimed to clarify whether nx-des-γ-carboxyprothrombin (nx-dcp) could become a new noninvasive model to predict liver fibrosis in hepatitis c virus (hcv) related liver disease.
منابع مشابه
Serum NX-DCP as a New Noninvasive Model to Predict Significant Liver Fibrosis in Chronic Hepatitis C
BACKGROUND Finding a noninvasive method to predict liver fibrosis using inexpensive and easy-to-use markers is important. OBJECTIVES We aimed to clarify whether NX-des-γ-carboxyprothrombin (NX-DCP) could become a new noninvasive model to predict liver fibrosis in hepatitis C virus (HCV) related liver disease. PATIENTS AND METHODS We performed a prospective cohort study on a consecutive grou...
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عنوان ژورنال:
hepatitis monthlyجلد ۱۵، شماره ۲، صفحات ۰-۰
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